Recent evidence appreciating the contribution of stromal cell heterogeneity in pathophysiology emerges as a new opportunity to stratify arthritic diseases and develop more targeted clinical tools. The project group postulates that different synovial fibroblast (SF) profiles determine the nature of Synovial MicroEnvironment (SME), and fuel the development of different types of arthritic diseases by exhibiting differential sensitivity to inflammatory stimuli. The ensuing transcriptional responses dictate the changes in the cellular composition of the diseased SMEs, characterizing the distinct pathological and clinical findings in each arthritic phenotype. Consistent with the hypothesis, the group aims to explore the stromal-mediated causalities in Psoriatic Arthritis (PsA) and delineate the PsA-specific SF profile. With the integrative transcriptomic and functional analyses, the group aspires to assist the generation of the distinct stromal codes governing arthritic diseases.