COVID-19 is are characterized by acute lung inflammatory disease and a strong systemic inflammatory response, termed “cytokine storm” that partially resembles other situations such as macrophage activation and autoinflammatory syndromes or CART therapy. The project investigates on the hypothesis that biological ageing and TS may be mechanistically linked to hyperinflammatory responses, and propose to investigate telomere shortening (TS) as a risk factor for severe disease and for long-term morbidity after recovery from acute COVID-19.
Project LeadJ L Pablos
The objective of the project is to better understand the relationship between ageing, previous chronic diseases (vascular, hypertension, diabetes) and the severity of COVID-19, through the study of a well-known process associated with aging: telomere shortening (TS).
Not immediate individual benefits expected. Future patients with COVID-19, or with future similar viral diseases could benefit.