Funded Research

A New Concept of ANCA-Associated Vasculitis (ANCA)
Cognitive phenotypes in immune mediated inflammatory diseases: a trans-diagnostic approach
Failing maternal-fetal tolerance in SLE: finding the molecular mechanisms behind pregnancy complications
PMR Research On Disease Mechanisms In Synovium (PROMIS)
Pro-fibrotic role of IgG4 antibodies in the pathogenesis of IgG4-related disease
Role of Innate Lymphoid Cells in Rheumatoid Arthritis
Role of Trained Immunity in the pathogenesis and treatment of Still’s disease
The role of immune effector fibroblast subsets in treatment refractory RA
The role of the intervertebral disc cartilage catabolites in Modic type 1 changes
Trends and factors associated with prescription opioid utilisation, dependence and deaths in patients with musculoskeletal conditions
Uncover the genetic basis of Spondyloarthritis to predict disease severity and to discover new drug targets
Uncovering musculoskeletal pain susceptibility profiles since childhood by bringing together population and clinical cohorts
Understanding barriers and facilitators to effective disease-management in Rheumatoid Arthritis to prevent refractory disease

A new therapeutic strategy for inhibiting pro-inflammatory macrophages in pre-clinical models of rheumatoid arthritis: using antagomir-155 encapsulated in pegylated liposomes
Epigenetic regulation by DAMPs underlying trained immunity in health and disease
Exploring the added value of lung densitometric and texture analysis of chest CT scans in the characterization of pre-capillary Pulmonary Hypertension (PH) in Systemic Sclerosis
Exploring treatment response in AS versus non-radiographic axSpA
Incidence and outcome of cardiovascular disease in patients with inflammatory joint diseases
Investigating patient related outcomes as tools for predicting disease in individuals at risk for developing arthritis
T cell-fibroblast interactive cell atlas in systemic sclerosis: Role of T cell exhaustion in tissue fibrosis
Tissue Profiling of the Th17 Gene Activity in AS

Applicability of standardized ultrasound examination to estimate disease activity in combination with JADAS and inflammation markers in JIA patients
Crosstalk of metabolic and epigenetic pathways in systemic sclerosis (SSc)
Effect of T-cell exhaustion profiles of synovial fluid and peripheral blood from JIA patients on disease pathogenesis and prognosis
Influence of metabolism on fibrosis in SSc

Does accelerated epigenetically defined ageing, including immune ageing, contribute to RA pathogenesis? Interaction in the development of RA
SEN-OA – Targeting senescent cells in osteoarthritis: an innovative therapeutic approach

Burden and impact of co-morbidity and frailty in patients with RMDs in Europe: a multi-national analysis of big healthcare data
Characterising comorbidity in patients with RA in Europe: a multi-national federated analysis of big healthcare data
Comorbidities in Osteoarthritis
Immune mediators and metabolites to stratify SLE patients at high risk of cardio vascular diseases (IMSLE)

Assessing the impact of COVID-19 on Rheumatic and Musculoskeletal Disorders in primary care: an observational study of UK national primary care electronic health records
Deciphering a specific signature of the immunosenescence induced in COVID-19+ patients versus rheumatoid arthritis patients
Telomere length in COVID-19: Biological aging and susceptibility to severe disease
The impact of COVID-19 and national COVID-19 policies on people with rheumatic diseases; the CORE (COVID-19 in rheumatic diseases) project
Whole Genome Sequencing in thrombo-inflammatory disorders triggered by SARS-CoV-2: machine learning applied to extensive immunological, genetic, and clinical datasets and implications for systemic rheumatic diseases

Autoimmune and molecular mechanisms for pain and fatigue in fibromyalgia
Exploring the effects of a combined exercise programme on pain and fatigue outcomes in people with systemic sclerosis
Targeting nociplastic pain in arthritis

Intrinsic regeneration of osteoarthritic cartilage by unloading involves peri-articular stem cell activity: a joint effort
Micro RNAs as biomarkers in OA
Pro-resolving mediators in OA: Homeostatic signals in the joint organ?
The partnership for early knee OA definition through imaging and tissue biomarkers (PEARL-OA)

A prediction score for individuals at risk for Systemic Lupus Erythematosus (SLE) by integrating clinical, serologic and transcriptomic data
Development of new tools for prediction and prevention of RA (PREDICT RA)
ENVI-RA: Impact of ENVIronmental factors and gene-environment interaction in the development of Rheumatoid Arthritis
Novel treatment targets in early-stage OA

BarrieR Integrity loss in Gut as driver of Host tissue Tropism and outcome in PsA: the BRIGHT concept
Identifying the mechanisms and biomarkers of transition from Psoriasis (PsO) to Psoriatic Arthritis (PsA)
The contribution of Stromal cells in shaping the Synovial MicroEnvironment of Psoriatic arthritis: pathogenetic mechanisms, Heterogeneity, and prognosis (StroPHe)

Comorbidity in Juvenile Idiopathic Arthritis (JIA)
European network of pregnancy registers in rheumatology (EuNeP)
IMPROVEMENT – Improving the outcome in myositis spectrum diseases: core set variables harmonization and use from children to adulthood
Pan-Nordic RA register network

Exploring the X-linked determinant implicated in the female susceptibility to rheumatic diseases
Sjögren’s syndrome leading to differential gene expression in males and females and functional impact on the immune system
Validation of sex-dependent molecular pain mechanisms in OA

Can inertial movement sensors (IMUs) provide a valid and reliable way of measuring Spinal Mobility in Axial Spondylo-arthritis (axSpa)? A clinimetric evaluation
Mechanistic studies of IL-17 versus TNF blockade in Spondyloarthritis (SpA)
Role of mucosal antigens for the pathogenesis of Spondyloarthritis (SpA)

START – Molecular stratification of patients with giant cell arteritis to tailor glucocorticoid and tocilizumab therapy
Stratified medicine in primary Sjögren’s syndrome

Deciphering the role of neutrophil reactive oxygen species (ROS) in the SLE pathogenesis
NET-ting the autoreactive B cell memory by therapeutically targeting the humoral autoimmunity in patients with SLE
Next generation sequencing (NGS) in peripheral blood and hematopoietic stem cells (HSC) in SLE: mechanisms of disease, novel therapeutic targets and biomarkers for disease activity and response to therapy
REFRACT – Refractory lupus nephritis: a tissue-based pathophysiological approach

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