The proposed project aims at better differentiating clusters of pre-capillary pulmonary hypertension (PH) in systemic sclerosis (SSc) patients, using radiomics automated computer technology for the quantification of the extent and the severity of lung fibrosis. The aim is to create clusters of SSc-PH patients, in the context of possible coexisting lung fibrosis, to really define prognosis and treatment impact.
Project LeadC Bruni
The study should provide a novel, automated classification workflow that will allow to classify patients into groups. Such classification, if shown significant by survival analysis, will allow for early detection of patients as high risks from those of lower risk. But at this stage, given the observational nature of the study, no direct patient involvement is requested, except for patient consent to data analysis if locally required. If the project will be successful, patients will be involved in multi-centric studies to validate the results and in future Randomised Clinical Trials (RCTs), as both active participant and as part of scientific advisory boards.