Osteoarthritis (OA) is the most common form of arthritis and a major cause of disability in older people. The prevalence of OA increases in the past 20 years(1). However, little has been done into its burden such as comorbidities. Our recent systematic review has found that people with OA are more likely to have other diseases, especially stroke, peptic ulcer, hypertension and depression(2). Whether these comorbidities just co-exist with, share common risk factors with or are causes or consequences of OA remains unknown.
Project LeadW Zhang
This project aims to examine:
Five work packages (WP) will be performed for these five objectives. Four national registration databases in the UK, Netherlands, Sweden and Spain will be used for WP1-3. Two cohort study databases (the UK Biobank and the Rotterdam study) will be used for WP4. Finally, data from different countries will be meta-analysed (WP5) to examine the consistency between countries and to pool results together as appropriate.
So far, UK and Sweden have been able to produce some results on the comorbidities associated with OA.
Swedish database studied the association with 18 conditions. UK database examined the association with 49 conditions before and after the diagnosis of OA. Besides, the clusters of comorbidities were explored among OA and matched controls using UK database.
Months 0-6: data extraction, cohort development, case/control matching, data cleaning, coding and validation
Months 7-24: complete WP1-3
Months 25-36: complete WP4-5
Three patient research partners (PRPs) are involved in the project since we applied for this project. They have actively participated in the meetings and shared their views on the list of conditions to be studied, possible ways of disseminations and the challenges they face because of the comorbidities.