Both TNF and IL-17A are pivotal pathogenic cytokines in SpA. In this project, we hypothesize that blockade of IL-17A and TNF affects different pathophysiological pathways.
Project LeadN Yeremenko
We aim to identify speciﬁc biological effects by systematic translational comparison of IL-17A versus TNF blockade in SpA patients using combined molecular, cellular and imaging approaches with the overall goal to establish a path towards stratiﬁed medicine.
A lay advisory board of patients will be instrumental in the interpretation of the data, in particular in addressing the question if and how the anticipated biologic proﬁles can be applied in a useful way to stratify individual patients or patient groups to aTNF versus aIL-17A treatment.