OA is still classified based on changes in joint tissues that are visible on conventional radiographs. This scoring system, however, does not accommodate emerging information about disease mechanisms.
Our proposal aimed to identify and validate miRNAs as future blood biomarkers for monitoring OA pathophysiological processes in cartilage via a 2 step approach:
- Identify miRNA signatures reporting on underlying disease processes and predicting severe OA of the hip and/or knee joint
- Validation and confirmation in additional cohorts across Europe and towards OA in additional joints such as hand OA.