Comorbidity in Juvenile Idiopathic Arthritis (JIA)

Concept

Comorbidity can be deﬁned as the presence of two disorders or more occurring at the same time in a single patient. Children with chronic diseases such as JIA can develop complications of the disease itself, a new disease or drug related side effects that have a signiﬁcant impact on the quality of life. In this project we want to study all signiﬁcant events occurring before or after the onset of arthritis.

Facts and figures

Project lead
N Wulffraat
UMC Utrecht

J.F.Swart@umcutrecht.nl

FOREUM research grant: € 300.000

2017–2020

Meet the team

N Wulffraat
UMC Utrecht

J Swart
UMC Utrecht

K Hyrich
University of Manchester

M Lunt
University of Manchester

L Kearsley-Fleet
University of Manchester

N Ruperto
Istituto Giannina Gaslini

G Giancane
IRCCS Istituto G. Gaslini

K Minden
Charité Berlin

J Klotsche
Charité Berlin

G Horneff
Charité Berlin

W Costello
European Network for Children with Arthritis ENCA

C Schoemaker
Dutch JIA parent organisation

Objectives

The purpose of this project is to study the presence of comorbidity and symptoms developing under therapy of patients followed in the 3 largest JIA registries in Europe. We assume that comorbidity in a disease such as JIA signiﬁcantly increases the burden of the disease and thus has major effects on quality of life.

Patient voice

ENCA (European Network for Children with Arthritis) representatives are part of our steering committee. ENCA has parents trained in research, epidemiology and health care amongst its members.

Patient involvement through ENCA can help us analysing the relevance of these complications for the disease burden. They will be actively involved in ranking the importance of the observed comorbidities/ complications and thus in discussing priorities for further research.

Interim results

three registries have identified the occurrence of selected comorbidities at registration and final follow-up. Furthermore, incidences on methotrexate and biologic therapy have been established. Currently, the registries are cooperating in the validation of a clinical prediction model for chronic uveitis.

Publications

A clinical prediction model for estimating the risk of developing uveitis in patients with juvenile idiopathic arthritis

J.W. van Straalen1, G. Giancane2,3, Y. Amazrhar1, Nikolay Tzaribachev4, Calin Lazar5, Yosef Uziel6, Albena Telcharova – Mihaylovska7, Claudio Len8, Angela Miniaci9, Alina Lucica Boteanu10, Giovanni Filocamo11, Mariel Viviana Mastri12, Thaschawee Arkachaisri13, Maria Greca Magnolia14, Esther Hoppenreijs15, S. de Roock1, N.M. Wulffraat1, Nicolino Ruperto2*, J.F. Swart1*, for the Paediatric Rheumatology International Trials Organisation (PRINTO) Submitted and under review

Abstracts EULAR 2019

OP0058: Development of inflammatory bowel disease during treatment with Etanercept in patients with Juvenile Idiopathic Arthritis