With the present research project we aim:
1. to demonstrate a direct pro-fibrotic effect of IgG4 antibodies from IgG4RD patients
2. to identify fibrotic molecular properties of IgG4 antibodies from IgG4RD patients
3. to explore the therapeutic potential of inhibiting the pro-fibrotic activity of IgG4 antibodies
In addition, the project will include a parallel work package conceived to engage patients over and beyond voluntary sample donation and discussion of scientific outputs. In particular, we will take advantage of this FOREUM Call and collaborate with experienced PRP in order to:
4. to identify IgG4RD specific “patient reported outcomes” (PRO) and develop the first ad hoc QoL questionnaire for IgG4RD (IgG4RD QoL).