Aim of this study is to determine the role of Trained Immunity in the pathogenesis of Still’s disease, and the therapeutic potential of inhibiting this mechanism for the treatment of this condition. Several factors are ideally aligned to achieve these ambitious research goals: a large cohort of patients with Still’s disease, an optimal experimental platform, and a synergistic enterprise with world-leading experts in the field.
Project LeadG Cavalli
In order to test the hypotheses the following aims are proposed:
This study is important to many patients with AOSD and SJIA, and many already volunteered to donate samples. In collaboration with AMRI (a non-profit patient organisation with investment in SD) there is a strong engagement of patients in the research process.
Regular updates on research findings, instructions on research strategies based on patients’ insight, and development for shared initiatives for effective dissemination of findings to societal stakeholders will be provided.