Ageing in RMDs

Rheumatic Musculoskeletal Diseases (RMDs) are among the most important conditions affecting health at different stages of life. Whether young, middle-aged or senior, changes in the function of the musculoskeletal system but also the responsiveness of the immune system occur thereby impacting the clinical manifestations of RMDs. Since life expectancy continuously increases in Europe, the understanding of ageing, as a physiological process as well as a factor influencing RMDs, becomes increasingly important.

FOREUM instigated a call for research proposal to support projects in the following areas:

  • Impact of age on the clinical manifestation, disease course and treatment of RMDs
  • Age-related functional decline of musculoskeletal function and frailty and their prevention and treatment
  • Physiological age-related changes of musculoskeletal cells and/or tissues involved in RMDs
  • Immune and inflammation changes related to ageing
  • Preclinical models to understand the role of ageing in RMD
  • Development of age-related standards in instruments used in the assessment of RMDs

15 letters of intent were received, peer reviewed and thoroughly evaluated. As a result, two projects are being funded.

SEN-OA Targeting senescent cells in OA
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Does epigenetic ageing contribute to RA pathogenesis?
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