WP1. A movie dedicated to the presentation of the SEN-OA project and to the feedback of two patient experts of one-day visit of a research laboratory on OA has been made.
WP2. Several types of samples in 3 non-clinical models of mice and humans with OA have been collected and are under evaluation for expression of senescence markers in various articular tissues.
WP3. Different in vitro (stem cells, chondrocytes) and in vivo (mouse, zebrafish) models of senescence have been developed. Senolytics are being evaluated in those models.
WP4. A preliminary screening was performed with a repurposing library to identify Senolytics and Pro-autophagy modulators in human chondrocytes. Several candidates are available for further validation.