This project aims to develop the first drug that can treat pain in osteoarthritis and restore the cartilage that has been lost and avoid joint replacement.
This research aims at validating ROR2-dependent biomarkers for patient selection and rapid efficacy assessment.
Aim 1: Generation and validation of a humanized monoclonal blocking antibody to ROR2
Aim 2: Stabilization of siRNA delivery
Aim 3: Biomarkers for patient selction and efficacy assesment