Intrinsic regeneration of osteoarthritic cartilage by unloading involves peri‐articular stem cell activity: a joint effort

Objectives of the Project

“Spontaneous” cartilage repair  has recently been recognized as proof of concept in man. The collaborative group will delineate the unknown mechanisms by which mesenchymal stem cells (MSCs) in the context of the intra‐articular milieu are involved in this repair activity ...

Read more

Facts and Figures

Project Lead
Prof. F. Lafeber
UMC Utrecht
FOREUM research grant: € 300.000
December 2015, Duration 3 years

Meet the Team

Prof. F. Lafeber
UMC Utrecht
Dr. S. Mastbergen
UMC Utrecht
Prof. D. McGonagle
University of Leeds
Prof. F. Berenbaum
Pierre and Marie Curie University, INSERM, AP-HP Saint-Antoine Hospital

Interim Results

So far, we are including patients and have performed related animal experiments which indicates that with joint distractions on the mRNA-level a regenerative process started.