NET-ting the autoreactive B cell memory by therapeutically targeting the humoral autoimmunity in patients with SLE

Objectives of the Project

Patients with SLE typically have circulating autoantibodies against DNA as a result of a humoral (auto-)immune response. The research project intends to  comprehensively study the pathophysiology of the humoral autoimmune response in SLE patients. To do so, we intend to establish an in-depth understanding of the origins of SLE-specifi c autoantibodies in a unique
cohort of SLE patients who are treated with new biological therapies specifi cally targeted
at the formation of autoantibodies.

Facts and Figures

Project Lead
Dr. Y K O Teng
UMC Leiden
FOREUM research grant: € 300.000
2016 - 2019

Meet the Team

Dr. Y K O Teng
UMC Leiden
Dr L van Dam
UMC Leiden
Prof. R Voll
Albert Ludwig University Freiburg
Prof. D Isenberg
University College London

Patient Voice

The experimental nature of our research proposal limits the potential contribution of patient research partners. It is however noteworthy that patient representatives are involved in the separate clinical trials at each collaborating centre which investigate therapeutic strategies that specifically target humoral autoimmunity.

Interim Results

Patients with SLE typically have circulating autoantibodies against DNA as a result of a humoral (auto-)immune response. This research project intends to  comprehensively study the pathophysiology of the humoral autoimmune response in SLE patients to establish an in-depth understanding of how autoantibodies  develop in  a unique cohort of SLE patients who are treated with new biological therapies specifically targeted at the formation of  autoantibodies. We have identified 38 refractory SLE patients with renal involvement who were treated with experimental treamtment regimens (i.e. rituximab, bortezomib or combination rituximab + belimumab). We are well on our way to perform in-depth analyses in these patients which eventually will inform us if and how these novel treatments influence the formation of autoantibodies in SLE patients.

Publications

LS Van Dam, T Kraaij, SW Kamerling, MC Avramut, CR Jost, AJ Koster, HU Scherer, CD Pusey AJ Rabelink, C van Kooten, YK Teng. Poster Presentations: Innate immunity in rheumatic diseases: SAT0015 Anca-associated vasculitis- and systemic lupus erythematosus-induced neutrophil extracellular traps have intrinsically different features. https://doi.org/10.1136/ANNRHEUMDIS-2017-EULAR.3804
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