Objectives of the Project
Several types of cells are involved in lupus including lymphocytes, monocytes, neutrophils and endothelial cells, all of which originate from hematopoietic stem cells. A comparative transcriptome profiling by RNA-seq in the peripheral blood and kidneys have been completed. The potential use of the discovered gene transcripts as biomarkers will be examined. RNA-seq studies will be extended to hematopoietic stem cells derived from both murine and human lupus samples.