Next Generation Sequencing (NGS) in Peripheral Blood and Hematopoietic Stem Cells (HSC) in SLE: Mechanisms of Disease, Novel Therapeutic Targets and Biomarkers for Disease Activity and Response to Therapy

Objectives of the Project

Several types of cells are involved in lupus including lymphocytes, monocytes, neutrophils and endothelial cells, all of which originate from hematopoietic stem cells. A comparative transcriptome profiling by RNA-seq in the peripheral blood and kidneys have been completed. The potential use of the discovered gene transcripts as biomarkers will be examined. RNA-seq studies will be extended to hematopoietic stem cells derived from both murine and human lupus samples.

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Facts and Figures

Project Lead
Prof. D. Boumpas
Biomedical Research Foundations, Academy of Athens
FOREUM research grant: € 300.000
March 2016, Duration 3 years
Publications

Meet the Team

Prof. D. Boumpas
Biomedical Research Foundations, Academy of Athens
Prof. G. Bertsias
University of Crete
Prof. F. Hiepe
Charité Universitätsmedizin
Prof. Ch. Pamfil
University of Medicine and Pharmacy
Prof. L. Rönnblom
Uppsala University
Prof. T. Vyse
Guy's Hospital, King's College