PEARL OA - Partnership for EARLy knee OsteoArthritis definition through imaging and tissue biomarkers

Objectives of the Project

Osteoarthritis (OA) is the fastest growing cause of disability worldwide. The development of OA structural and symptom-modifying therapy is hampered by the complex phenotypes of this disease and difficulties in accurate quantification of OA pathologies. Defining early states of the OA process will...

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Facts and Figures

Project Lead
Prof. P. Conaghan
University of Leeds
FOREUM pump prime grant: € 75.000

Meet the Team

Prof. P. Conaghan
University of Leeds
Prof. R. Frobell
Lund University


On the basis of the 3D imaging biomarkers evolved through this grant, the applicants were part of a successful IMI application, APPROACH-OA, which will utilise these biomarkers to further explore the relationship of bone to OA development and progression.

Using the large American NIH Osteoarthritis Initiative cohort, which includes people at risk of developing OA, we were able to show...

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The relationship between three-dimensional knee MRI bone shape and total knee replacement-a case control study: data from the Osteoarthritis Initiative. Barr AJ, Dube B, Hensor EM, Kingsbury SR, Peat G, Bowes MA, Sharples LD, Conaghan PG.

Rheumatology (Oxford). 2016 Sep;55(9):1585-93. doi: 10.1093/rheumatology/kew191