Pro-resolving mediators in Osteoarthritis: Homeostatic signals in the joint organ?

Objectives of the Project

Infl ammation is a key component of OA in a large number of patients and a clear therapeutic
target. This project explores the impact of molecules produced in the joint that have anti-inflammatory properties.
Such molecules are used by the body to limit the impact of inflammation. Understanding their production and effects in patients with joint disease could help in better controlling the deleterious effects of inflammation on the tissues of the joint, in particular the cartilage and the bone.

Facts and Figures

Project Lead
Prof. R. Lories
KU Leuven
FOREUM research grant: € 300.000
November 2014, Duration 3 years

Meet the Team

Prof. R. Lories
KU Leuven
Prof. P. L. Meroni
University of Milano
Prof. O. de Lucia
University of Milano
Prof. A. Ioan- Facsinay
UMC Leiden
Prof. Z. Szekanecz
University of Debrecen

Patient Voice

For this laboratory project, based on novel technologies, patients have not been directly involved in the design of the experiments.

However, the development of novel strategies will clearly benefit the patients.

In accordance with the EULAR perspective on patient involvement, trained patients participate in the consortium meetings not only to update the community about our research but to add their perspective to the progress of the work.

Interim results

Several pro-resolving molecules are found In the synovial fluid of patients with RMDs. Their detection is a challenging procedure that the consortium further optimized. Preliminary data are currently validated in a larger cohort of patients.

Publications

Jónasdóttir HS, Brouwers H, Kwekkeboom JC, van der Linden HM, Huizinga T, Kloppenburg M, Toes RE, Giera M, Ioan-Facsinay A. Targeted lipidomics reveals activation of resolution pathways in knee osteoarthritis in humans. Osteoarthritis and Cartilage. 2017 Feb 8. pii: S1063-4584(17)30839-7. doi: 10.1016/j.joca.2017.01.018. [Epub ahead of print].

Link to publication