Pro-resolving mediators in OA: Homeostatic signals in the joint organ?

Objectives of the Project

Infl ammation is a key component of OA in a large number of patients and a clear therapeutic
target. This project explores the impact of molecules produced in the joint that have anti-inflammatory properties.
Such molecules are used by the body to limit the impact of inflammation. Understanding their production and effects in patients with joint disease could help in better controlling the deleterious effects of inflammation on the tissues of the joint, in particular the cartilage and the bone.

Facts and Figures

Project Lead
Prof. R Lories
KU Leuven
FOREUM research grant: € 300.000
2014 - 2018

Meet the Team

Prof. R Lories
KU Leuven
Prof. P L Meroni
University of Milano
Prof. O. de Lucia
University of Milano
Prof. A Ioan- Facsinay
UMC Leiden
Prof. Z Szekanecz
University of Debrecen

Patient Voice

For this laboratory project, based on novel technologies, patients have not been directly involved in the design of the experiments.

However, the development of novel strategies will clearly benefit the patients.

In accordance with the EULAR perspective on patient involvement, trained patients participate in the consortium meetings not only to update the community about our research but to add their perspective to the progress of the work.

Final Results

Inflammation is the hallmark feature of many rheumatic and musculoskeletal diseases. The importance of inflammation is a factor that contributes to the severity and symptoms of osteoarthritis which was traditionally considered as degenerative joint disease.
Final report

Publications

  • Ioan-Facsinay A, Kloppenburg M. Bioactive lipids in osteoarthritis: risk or benefit? Curr Opin Rheumatol. 2018 Jan;30(1):108-113. doi:10.1097/BOR.0000000000000463. PubMed PMID: 29035931.
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  • Monteagudo S, Cornelis FMF, Aznar-Lopez C, Yibmantasiri P, Guns LA, Carmeliet P, Cailotto F, Lories RJ. DOT1L safeguards cartilage homeostasis and protectsagainst osteoarthritis. Nat Commun. 2017 Jun 19;8:15889. doi: 10.1038/ncomms15889. PubMed PMID: 28627522; PubMed Central PMCID: PMC5481839.
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  • Ioan-Facsinay A, Kloppenburg M. Osteoarthritis: Inflammation and fibrosis in adipose tissue of osteoarthritic joints. Nat Rev Rheumatol. 2017 Jun;13(6):325-326. doi: 10.1038/nrrheum.2017.53. Epub 2017 Apr 13. PubMed PMID: 28405000.
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  • Jónasdóttir HS, Brouwers H, Kwekkeboom JC, van der Linden HM, Huizinga T, Kloppenburg M, Toes RE, Giera M, Ioan-Facsinay A. Targeted lipidomics reveals activation of resolution pathways in knee osteoarthritis in humans. Osteoarthritis and Cartilage. 2017 Feb 8. pii: S1063-4584(17)30839-7. doi: 10.1016/j.joca.2017.01.018. [Epub ahead of print].
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  • van der Kraan PM, Berenbaum F, Blanco FJ, Cosimo de B, Lafeber F, Hauge E, Higginbottom A, Ioan-Facsinay A, Loughlin J, Meulenbelt I, Moilanen E, Pitsillidou I, Tsezou A, van Meurs J, Vincent T, Wittoek R, Lories R; EULAR Study group in OA. Translation of clinical problems in osteoarthritis into pathophysiological research goals. RMD Open. 2016 May 26;2(1):e000224. doi:10.1136/rmdopen-2015-000224. eCollection 2016. Erratum in: RMD Open. 2016 Oct7;2(2):e000224corr1. PubMed PMID: 27252894; PubMed Central PMCID: PMC4885448.
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  • Brouwers H, von Hegedus J, Toes R, Kloppenburg M, Ioan-Facsinay A. Lipidmediators of inflammation in rheumatoid arthritis and osteoarthritis. Best Pract Res Clin Rheumatol. 2015 Dec;29(6):741-55. doi: 10.1016/j.berh.2016.02.003. Epub 2016 Mar 4. Review. PubMed PMID: 27107510.
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  • van der Kraan PM, Berenbaum F, Blanco FJ, Cosimo de B, Lafeber F, Hauge E, Higginbottom A, Ioan-Facsinay A, Loughlin J, Meulenbelt I, Moilanen E, Pitsillidou I, Tsezou A, van Meurs J, Vincent T, Wittoek R, Lories R; Translation of clinical problems in osteoarthritis into pathophysiological research goals. RMD Open. 2016 May 26;2(1):e000224. doi: 10.1136/rmdopen-2015-000224. eCollection 2016.
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  • Brouwers H, von Hegedus J, Toes R, Kloppenburg M, Ioan-Facsinay A. Lipid mediators of inflammation in rheumatoid arthritis and osteoarthritis. Best Pract Res Clin Rheumatol. 2015 Dec;29(6):741-55. doi: 10.1016/j.berh.2016.02.003. Epub 2016 Mar 4. Review. PubMed PMID: 27107510.
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  • de Jong AJ, Kloppenburg M, Toes RE, Ioan-Facsinay A. Fatty acids, lipid mediators, and T-cell function. Front Immunol. 2014 Oct 13;5:483. doi: 10.3389/fimmu.2014.00483. eCollection 2014. Review. PubMed PMID: 25352844; PubMed Central PMCID: PMC4195378.
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