ENVI-RA: Impact of ENVIronmental factors and gene-environment interaction in the development of Rheumatoid Arthritis

Concept

Rheumatoid arthritis (RA) is a complex di- sease in which environmental agents are thought to interact with genetic factors to trigger auto-immunity.

The contribution of genetic factors to RA susceptibility is well recognized. The heritability of anticitrullinated protein auto- antibody (ACPA)-positive and ACPA-negative RA implicates different genes [2]. To date, the main known genetic factoris HLA, in particular the HLA-DRB1-shared epitope (SE) alleles, that predispose much more strongly to ACPA. However, the concordance for RA between monozygotic twins is only 15.6%. Thus, environment plays a crucial role in the development of the disease as well.

Facts and figures

Project lead
R Seror
Université Paris Sud
raphaele.se@gmail.com
FOREUM research grant: € 100.000
2018 - 2021

Meet the team

R Seror
Université Paris Sud
D van der Woude
UMC Leiden
C Boutron
Gustave Roussy Institute
D Alpízar-Rodríguez
Hôpitaux Universitaires de Genève
P Preiss
Association France Polyarthrite

Objectives

This project aims to investigate the role of new environmental factors and of potential interactions between the genetic background and specific environmental factors in the development of RA and/or preclinical phases of RA.

Patient voice

Patients will be involved at each step: For case validation, for interpreting/discuss results of research, and they will help pro- viding key message derived from research results to other patients. Patients from dif- ferent countries will be involved to input different view and perspectives.