Influence of metabolism on fibrosis in SSc

Objectives of the Project

Systemic sclerosis (SSc) is a chronic autoimmune disease of unknown cause, which leads to disability and may cause premature death. SSc is characterized by massive accumulation of extracellular matrix proteins (=fibrosis) in skin and internal organs with permanent loss of
organ function.
Decreasing/reversing fibrosis in patients with SSc can improve the prognosis of thisdevastating disease. Drugs that influence metabolic pathways could reduce the production of extracellular matrix proteins by fibroblasts in SSc. This represents a promising new treatment strategy in SSc.

Facts and Figures

Project lead
MD B Burja
University Medical Centre Ljubljana
FOREUM research grant: €140.00
2018 - 2021

Meet the team

MD B Burja
University Medical Centre Ljubljana
Prof. Dr. M Tomsic
University Medical Centre Ljubljana
Dr. K Lakota
University Medical Centre Ljubljana
Prof. O Distler
University of Zurich
Dr. M Frank-Bertoncelj
University of Zurich