Incidence and outcome of cardiovascular disease in patients with inflammatory joint diseases

Concept

Several studies have described an increased risk of cardiovascular diseases (CVD) in patients with inflammatory jont diseases (IJD), but some aspects of this phenomenon are surprisingly poorly understood and studied. This project will fill several important evidence gaps and the goal is that the results from this project may form a much needed cornerstone for CVD prevention guidelines specifically developed for patients with IJD. These tailored guidelines may eventually reduce the excess CVD burden for this high CVD risk patient population, for whom currently there is a large unmet need for improved CVD preventive care.

Facts and figures

Project lead
A Kerola
University of Helsinki
anne.kerola@helsinki.fi
FOREUM reserach grant: €50'000
2019 - 2020

Meet the team

A Kerola
University of Helsinki
M Kauppi
Päijät-Häme Central Hospital
T Nieminen
Päijät-Häme Central Hospital
A Semb
Diakonhjemmet Hospital
E Haarvardsholm
Diakonhjemmet Hospital

Objectives

The overarching goal for this project is to compare Norwegian data (2008-2017) on cardiovascular diseases (CVD) in patients with inflammatory joint diseases (IJD) (rheumatoid arthritis, ankylosing
spondylitis and psoriatic arthritis) with similar Finnish register data from 2008-2017. First, data on the hypotheses in the Norwegian patients with IJD and general population controls are being explored, and secondly the results will be validated with data from the Finnish registers.
The objectives include
1) to evaluate all-cause and CVD morbidity and mortality in patients with IJD compared to the general population,
2) to compare the prevalence of CVD in users and non-users of biologic disease-modifying antirheumatic drugs (bDMARDs) in patients with IJD and the general population,
3) to explore sex differences in CVD event rates in patients with IJD compared to the general population.